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Open Access Journal Article

Formulation and evaluation of medicated microemulsion for topical application

by Mohamed E. Abdelrahim 1,* ,  Ahmed Abdelbary 2  and  Mahmoud Ghorab 2
1
Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt.
2
Faculty of Pharmacy, Cairo University, Giza, Egypt.
*
Author to whom correspondence should be addressed.
IJCMR  2024, 27; 2(3), 27; https://doi.org/10.61466/ijcmr2030002
Received: 29 January 2024 / Accepted: 4 May 2024 / Published Online: 5 May 2024
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Abstract

Backgroungs

Microemulsion is a clear thermodynamically stable dispersion of two immiscible liquids with carefully adjusted emulsifier(s). It can be used as a vehicle for many different drugs and dosage forms.

Methods

To formulate a microemulsion for topical use from cheap components a pseudoternary phase diagrams were constructed with formulae consisting of paraffin oil, cosurfactant (sorbitol or glycerol), surfactant (Brij97) and water. The existence of microemulsion regions was demonstrated.

Indomethacin was added to the best formulae, which produce microemulsions in gel form and evaluating them for their physical characters, release rate, physical and chemical stability and Pharmacodynamic.

Results

Fifty five formulae produce stable microemulsions in gel form. On incorporation of indomethacin only four formulae remain stable, clear formulae. They were used for further studies. Their order of drug release rate was first order. The four formulae were stable when stored at room temperature, or under stress. Shelf life of them would be minimum of 492 days and maximum of 712 days.

Indomethacin significantly inhibits edema, induced in rat paw by different percentage. Effect of the prepared microemulsions were between the effect of commercial injection form, highest effect, and commercial topical form, lowest effect.

Conclusions

The microemulsion formulae prepared with paraffin oil, brij97, sorbitol or glycerol and water showed acceptable physical properties, drug release, stability and Pharmacodynamic effect.

Keywords: indomethacin; microemulsion; Paraffin oil; water; surfactant; cosurfactant;
Copyright: © 2024 by Abdelrahim, Abdelbary and Ghorab. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Abdelrahim, M. E.; Abdelbary, A.; Ghorab, M. Formulation and evaluation of medicated microemulsion for topical application. International Journal of Clinical Medical Research, 2024, 2, 27. https://doi.org/10.61466/ijcmr2030002
AMA Style
Abdelrahim M E, Abdelbary A, Ghorab M. Formulation and evaluation of medicated microemulsion for topical application. International Journal of Clinical Medical Research; 2024, 2(3):27. https://doi.org/10.61466/ijcmr2030002
Chicago/Turabian Style
Abdelrahim, Mohamed E.; Abdelbary, Ahmed; Ghorab, Mahmoud 2024. "Formulation and evaluation of medicated microemulsion for topical application" International Journal of Clinical Medical Research 2, no.3:27. https://doi.org/10.61466/ijcmr2030002

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