Open Access Journal Article

Formulation and evaluation of medicated microemulsion for topical application

by Mohamed E. Abdelrahim 1,* Ahmed Abdelbary 2  and  Mahmoud Ghorab 2
Faculty of Pharmacy, Beni Suef University, Beni Suef, Egypt.
Faculty of Pharmacy, Cairo University, Giza, Egypt.
Author to whom correspondence should be addressed.
IJCMR  2024, 27; 2(3), 27;
Received: 29 January 2024 / Accepted: 4 May 2024 / Published Online: 5 May 2024



Microemulsion is a clear thermodynamically stable dispersion of two immiscible liquids with carefully adjusted emulsifier(s). It can be used as a vehicle for many different drugs and dosage forms.


To formulate a microemulsion for topical use from cheap components a pseudoternary phase diagrams were constructed with formulae consisting of paraffin oil, cosurfactant (sorbitol or glycerol), surfactant (Brij97) and water. The existence of microemulsion regions was demonstrated.

Indomethacin was added to the best formulae, which produce microemulsions in gel form and evaluating them for their physical characters, release rate, physical and chemical stability and Pharmacodynamic.


Fifty five formulae produce stable microemulsions in gel form. On incorporation of indomethacin only four formulae remain stable, clear formulae. They were used for further studies. Their order of drug release rate was first order. The four formulae were stable when stored at room temperature, or under stress. Shelf life of them would be minimum of 492 days and maximum of 712 days.

Indomethacin significantly inhibits edema, induced in rat paw by different percentage. Effect of the prepared microemulsions were between the effect of commercial injection form, highest effect, and commercial topical form, lowest effect.


The microemulsion formulae prepared with paraffin oil, brij97, sorbitol or glycerol and water showed acceptable physical properties, drug release, stability and Pharmacodynamic effect.

Copyright: © 2024 by Abdelrahim, Abdelbary and Ghorab. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Abdelrahim, M. E.; Abdelbary, A.; Ghorab, M. Formulation and evaluation of medicated microemulsion for topical application. International Journal of Clinical Medical Research, 2024, 2, 27.
AMA Style
Abdelrahim M E, Abdelbary A, Ghorab M. Formulation and evaluation of medicated microemulsion for topical application. International Journal of Clinical Medical Research; 2024, 2(3):27.
Chicago/Turabian Style
Abdelrahim, Mohamed E.; Abdelbary, Ahmed; Ghorab, Mahmoud 2024. "Formulation and evaluation of medicated microemulsion for topical application" International Journal of Clinical Medical Research 2, no.3:27.

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  1. Brien, M.O. and J. McCsuley, Indomethacin, in Analytical Profiles of Drug substances, K. Florey, Ed., Academic Press, Inc., Editor. 1984: San Diego, California, USA,. p. 211.
  2. Constantinides, P.P., Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharmaceutical research, 1995. 12(11): p. 1561-1572.
  3. Vandamme, T.F., Microemulsions as ocular drug delivery systems: recent developments and future challenges. Progress in Retinal and Eye Research, 2002. 21(1): p. 15-34.
  4. D'Cruz, O.J. and F.M. Uckun, Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles. Contraception, 2001. 64(2): p. 113-123.
  5. Sintov, A.C. and S. Botner, Transdermal drug delivery using microemulsion and aqueous systems: influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. International journal of pharmaceutics, 2006. 311(1-2): p. 55-62.
  6. Berthod, A., O. Nicolas, and M. Porthault, Water in oil microemulsions as mobile phase in liquid chromatography. Analytical Chemistry, 1990. 62(14): p. 1402-1407.
  7. Marsh, A., B. Clark, and K. Altria, Oil-in-water microemulsion high performance liquid chromatographic analysis of pharmaceuticals. Chromatographia, 2004. 59(9): p. 531-542.
  8. Pascoe, R. and J.P. Foley, Rapid separation of pharmaceutical enantiomers using electrokinetic chromatography with a novel chiral microemulsion. The Analyst, 2002. 127(6): p. 710-714.
  9. Bhargava, H., A. Narurkar, and L. Lieb, Using microemulsions for drug delivery. Pharm. Technol, 1987. 41(3).
  10. Aboofazeli, R., D. Barlow, and M. Lawrence, Particle Size Analysis of Concentrated Phospholipid Microemulsions: II. Photon Correlation Spectroscopy. APPS PharmSci, 2000. 41(3).
  11. Kreilgaard, M., Influence of microemulsions on cutaneous drug delivery. Advanced drug delivery reviews, 2002. 54: p. S77-S98.
  12. Winter, C.A., E.A. Risley, and G.W. Nuss, Carrageenan-induced oedema in hind paw of rat as an assay for antiinflammatory drugs. . Proc. Soc. Exp. Biol. and Med., 1962. 111: p. 544-547.
  13. Flynn, G.L., S.H. Yalkowsky, and T.J. Roseman, Mass transport phenomena and models: Theoretical aspects. J. Pharm. Sci, 1974. 63: p. 479.
  14. Binks, B.P., Particles as surfactants--similarities and differences. Current Opinion in Colloid & Interface Science, 2002. 7(1-2): p. 21-41.
  15. Chidambaram, N. and D.J. Burgess, Emulsions: Design and Manufacturing. Injectable dispersed systems: Formulation, processing and performance: p. 213-248.
  16. Loth, M., C. Blanvalet, and B. Valange, Stable microemulsion cleaning composition, 1992, Google Patents.
  17. Lawrence, M.J., Microemulsions as drug delivery vehicles. Curr Opin Colloid Sci., 1996. 1: p. 826-832.