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Articles ( Showing 1-20 of 50 items)
Open Access Letter
The neurochemical underpinnings of autism spectrum disorder
by Farah Amirah
Abstract
Autism spectrum disorder encompasses a range of neurobehavioral and neurodevelopmental conditions marked by deficits in social interaction and communication, as well as restricted and repetitive behaviors or interests, alongside atypical sensory processing. Environmental, immunological, genetic, and epigenetic factors contribute to the pathophysiology of autism, triggering neur [...] Read more

Open Access Short Communication
Future directions of diagnostic and therapeutic strategies specific to subtypes of small cell lung cancer
by Carl Define
Abstract
Small cell lung cancer exhibits rapid proliferation and significant metastatic potential. There are significant epidemiologic and biological associations with tobacco carcinogens. While most small cell lung cancers display neuroendocrine characteristics, a significant subset of tumors does not possess these features. Genomic profiling of small cell lung cancer demonstrates gene [...] Read more

Open Access Journal Article
The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension in different degrees
by Mykhailo Lutai , Ilona Golikova  and  Nataliia Chubko
Abstract
The use of beta-blockers (bisoprolol) and ACE inhibitors (perindopril) is pathogenetically and clinically justified in patients with stable coronary artery disease (CAD) and concomitant arterial hypertension (AH) . The study showed that prescribing a fixed combination of previously used drugs (perindopril, bisoprolol) for 4 weeks in patients with clinical symptoms or documented [...] Read more

Open Access Letter
Future of artificial intelligence applications in Joint trauma
by Valentina Sebastian
Abstract
Joint trauma constitutes a substantial proportion of emergency room visits and patients requiring urgent care, imposing considerable financial burdens on society. Diagnostic imaging is essential in the evaluation and treatment of trauma victims. Diagnostic imaging constitutes a complex, multifaceted system, with numerous elements of its workflow susceptible to inefficiencies or [...] Read more

Open Access Journal Article
Hybrid Image Features Supported Normal/Abnormal Retinal Optical Coherence Tomography Image Classification
by Aleksandrs Mārtiņš
Abstract
Background Eye is one of the primary sensory organs, responsible to provide the necessary visual information to the brain. Any abnormality in eye cause mild to severe vision issues and hence appropriate detection and treatment is preferred. Clinical level examination of the eye is commonly performed using image examination procedures and this work considered the Optical Cohere [...] Read more

Open Access Review
Hyperbaric oxygen therapy for cerebral palsy
by Lopez Morales
Abstract
Synopsis In a hyperbaric chamber pressurized to more than one atmosphere, 100% oxygen is inhaled as part of hyperbaric oxygen therapy. Several indications for this treatment, such as decompression sickness, carbon monoxide poisoning, serious burns, or chronic infections, have been approved. Based mainly on enhancing oxygen availability to injured brain cells with potential for [...] Read more

Open Access Communication
The impact of telerehabilitation therapies and information and communication technology on stroke recovery
by Roberts Aleksandrs
Abstract
A novel approach to offering stroke survivors rehabilitation services is telerehabilitation. Providing mainstream therapies for mobility, cognitive, speech and language, and other problems is a promising strategy. Information and communication technologies and stroke therapies are the two main pillars of telerehabilitation. Information and communication technology offer a platf [...] Read more

Open Access Review
Signal transductions and nonalcoholic fatty liver
by Michael Sebastian
Abstract
Nonalcoholic fatty liver disease is a common liver disease, and the incidence increases year by year. The pathogenesis of nonalcoholic fatty liver disease is correlated with insulin resistance and oxidative stress, which induces varied inflammatory cytokines (tumor necrosis factor-α, interleukin-1, interleukin-6, etc). Different signal transductions, such as mitogen-activ [...] Read more

Open Access Communication
Immediate and long-term effects of COVID-19's on the pharmaceutical industry
by Julez Audrick
Abstract
On March 11, 2020, the WHO declared the new coronavirus disease 2019 (COVID-19) to be a worldwide pandemic. This pandemic has significant repercussions on the pharmaceutical industry and the health market. These effects could manifest in the short or long term and require planning and detection to lessen their socioeconomic cost. This brief communication research evaluated the [...] Read more

Open Access Review Article
Effective nursing care and management of bariatric surgery for obesity
by Arjunan Sundaresan
Abstract
Obese people are susceptible to health complications and diseases, such as cardiovascular disorders, type 2 diabetes, hypertension, osteoarthritis, gallstone, hypoxia, certain cancers and even mental and intellectual and disabilities. Bariatric surgery is a prevalent weight loss approach, predominantly in situations where prior efforts towards weight reduction proved ineffectiv [...] Read more

Open Access Original Study
The effect of laparoscopy versus open appendectomy on wound infection in elderly subject: A meta-analysis
by Mohammed A. Amin  and  Marina E. Boules
Abstract
Backgrounds The purpose of the meta-analysis was to evaluate and compare the effect of laparoscopy versus open appendectomy on wound infection in elderly subjects. Methods The results of this meta-analysis were analyzed, and the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random or fixed effec [...] Read more

Open Access Original Study
A meta-analysis examining the effects of traditional therapy versus negative-pressure therapy on wound infection and graft take rates in skin with split thickness after grafting surgery
by Juliette Louis  and  Béatrice Alain
Abstract
Backgrounds The purpose of the meta-analysis was to evaluate and compare the effects of negative-pressure wound therapy (NPWT) with conventional therapy (CT) on wound infection and graft take rates in split-thickness skin (STS) after grafting surgery (GS). Methods The results of this meta-analysis were analyzed, and the odds ratio (OR) and mean difference (MD) with 95% confi [...] Read more

Open Access Review
Pyrrolizines: natural and synthetic derivatives with diverse biological activities
by Samir M. El-Moghazy Aly , Mohamed A. Azim Mohamed , Ahmed M. Shawky , Faisal A. Almalki , Ashraf N. Abdalla , Bahaa G.M. Youssif , Ahmed H. Abdelazeem , Nashwa, A. Ibrahim  and  Ahmed M. Gouda
Abstract
The pyrrolizine nucleus is a bicyclic ring system that consists of a pyrrole ring fused to another pyrrolidin ring. It constitutes the basic skeleton in many natural and synthetic compounds with diverse biological activities such as the anti-inflammatory, nootropic, antiemetic, antibacterial, antiviral, anticonvulsant, antiarrhythmic, and anticancer activities. At least two of [...] Read more

Open Access Review Article
Oral Mucosal Absorption: Mechanisms, Methods, and Challenges in Drug Delivery
by Ossama M. Sayed
Abstract
This review focuses on the mechanisms and methods involved in oral mucosal absorption, with a particular emphasis on drug delivery systems. It begins by discussing the protective role of saliva in the oral cavity, highlighting its importance in maintaining the health of the oral tissues and facilitating drug delivery. The review then delves into the mechanisms of oral mucosal a [...] Read more

Open Access Journal Article
Effectiveness of Postoperative Systemic Antibiotic Prophylaxis Following Cardiovascular Implantable Electronic Device Implantation: A Systematic Review and Meta-Analysis
by Hanaa Elshazly
Abstract
Background Cardiac implantable electronic devices (CIED) represent established life-sustaining interventions for various cardiac conditions, but post-placement infections are associated with high morbidity and mortality. Although pre-procedural antibiotic prophylaxis effectively reduces CIED infection rates, limited data exist on post-procedural antibiotic use, especially beyo [...] Read more

Open Access Journal Article
A meta-analysis examining the impact of antibiotic prophylaxis on surgical site wound infection during third molar surgery
by Zhang Wong
Abstract
Backgrounds The meta-analysis aims to estimate the effect of antibiotic prophylaxis (AP) on surgical site wound infection (SSWI) in third molar surgery (TMS). Methods Examinations comparing AP to placebo for TMS were utilized in the meta-analysis from various languages that met the inclusion criteria. Using dichotomous random or fixed effect models, the results of these inv [...] Read more

Open Access Journal Article
Effect of Chinese herbal medicine as an adjunctive technique to standard treatment for personal with diabetic foot ulcers: A meta-analysis
by Longe Jiany  and  Weneewen Xiu
Abstract
Background The purpose of the meta-analysis was to evaluate and contrast Chinese herbal medicine's effectiveness as a supplement to conventional treatment for diabetic foot ulcers. Methods The results of this meta-analysis were analyzed using dichotomous or contentious random or fixed effect models, and the odds ratio (OR) and mean difference (MD) with 95% CIs were calculated. [...] Read more

Open Access Journal Article
Phosphate-specific diet effect on serum phosphate levels in adults undergoing hemodialysis: A meta-analysis
by Zhumeei Giong  and  Nai Lie
Abstract
Background We performed a meta-analysis to evaluate the influence of a phosphate-specific intake on serum phosphate levels in hemodialysis subjects. Methods A systematic literature search up to November 2021 was done and 14 studies included 1284 hemodialysis subjects at the start of the study; 671 of them were provided with phosphate-specific intake, and 613 were control. W [...] Read more

Open Access Journal Article
A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies
by Yaieo Koang
Abstract
Background: A meta-analysis research was implemented to appraise gingival wound healing management by photobiomodulation as adjunctive management to periodontal treatments. Inclusive literature research till April 2023 was done and 908 interconnected researches were revised. Methods The 9 picked researches, enclosed 517 periodontal disease persons were in the utilized resear [...] Read more

Open Access Journal Article
A meta-analysis looking at the effects of continuous management for complications related to intraoperative pressure wound ulcers in women with breast cancer
by Ruei Gu  and  Guoemei Xu
Abstract
Backgrounds A meta-analysis research was executed to appraise the effect of the continuous intervention for intraoperative pressure wound ulcers (IOPWUs) associated problems in breast cancer (BC) females. Methods Inclusive literature research till March 2023 was done and 436 interconnected researches were revised. The 8 picked researches, enclosed 1267 BC females were in the [...] Read more