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cardiovascular anti-inflammatory infection polymers mucoadhesion mucosa Epithelial Diffusion Buccal binding interactions anticancer antibiotic mechanism of action pyrrolizine open appendectomy laparoscopy surgical site infection elderly split-thickness skin conventional therapy
Open Access Journal Article

A meta-analysis examining the effects of traditional therapy versus negative-pressure therapy on wound infection and graft take rates in skin with split thickness after grafting surgery

by Juliette Louis 1  and  Béatrice Alain 1
1
Jean Minjoz Hospital, 3 Bd Alexandre Fleming, 25000 Besançon, France
*
Author to whom correspondence should be addressed.
IJCMR  2024 2(5):40; https://doi.org/10.61466/ijcmr2050005
Received: 1 July 2024 / Accepted: 25 September 2024 / Published Online: 27 September 2024
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Abstract

Backgrounds

The purpose of the meta-analysis was to evaluate and compare the effects of negative-pressure wound therapy (NPWT) with conventional therapy (CT) on wound infection and graft take rates in split-thickness skin (STS) after grafting surgery (GS).

Methods

The results of this meta-analysis were analyzed, and the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random or fixed effect models. For the current meta-analysis, 16 examinations spanning from 2002 to 2023 were included, encompassing 1301 people with STSs after GS.

Results

NPWT had a significantly lower wound infection (OR, 0.29; 95% CI, 0.17-0.48, p<0.001), and higher graft take rate (MD, 8.70; 95% CI, 5.76-11.63, p<0.001) compared to CT in STSs after GS subjects.

Conclusions

The examined data revealed that NPWT had a significantly lower wound infection and a higher graft take rates compared to CT in STSs after GS subjects. However, given that several examinations had a small sample size, consideration should be given to their values.

Keywords: grafting surgery; negative-pressure wound therapy; conventional therapy; split-thickness skin;
Copyright: © 2024 by Louis and Alain. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Louis, J.; Alain, B. A meta-analysis examining the effects of traditional therapy versus negative-pressure therapy on wound infection and graft take rates in skin with split thickness after grafting surgery. International Journal of Clinical Medical Research, 2024, 2, 40. doi:10.61466/ijcmr2050005
AMA Style
Louis J, Alain B. A meta-analysis examining the effects of traditional therapy versus negative-pressure therapy on wound infection and graft take rates in skin with split thickness after grafting surgery. International Journal of Clinical Medical Research; 2024, 2(5):40. doi:10.61466/ijcmr2050005
Chicago/Turabian Style
Louis, Juliette; Alain, Béatrice 2024. "A meta-analysis examining the effects of traditional therapy versus negative-pressure therapy on wound infection and graft take rates in skin with split thickness after grafting surgery" International Journal of Clinical Medical Research 2, no.5:40. doi:10.61466/ijcmr2050005

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