There isn't a COVID-19 vaccination or particular antiviral drug available yet. In order to preserve lives and stop the disease's spread, a readily available, efficient, and secure therapy is desperately needed. Acute respiratory distress syndrome plays a major role in COVID-19 death rates. The characteristic of acute respiratory distress syndrome is markedly elevated oxidative stress brought on by a fast release of free radicals and cytokines (cytokine storm), which can result in organ failure, cellular damage, and even death. We describe a case where the patient responded well to early administration of high dose intravenous vitamin C in addition to other nutrients and drugs.

Backgroungs

Microemulsion is a clear thermodynamically stable dispersion of two immiscible liquids with carefully adjusted emulsifier(s). It can be used as a vehicle for many different drugs and dosage forms.

Methods

To formulate a microemulsion for topical use from cheap components a pseudoternary phase diagrams were constructed with formulae consisting of paraffin oil, cosurfactant (sorbitol or glycerol), surfactant (Brij97) and water. The existence of microemulsion regions was demonstrated.

Indomethacin was added to the best formulae, which produce microemulsions in gel form and evaluating them for their physical characters, release rate, physical and chemical stability and Pharmacodynamic.

Results

Fifty five formulae produce stable microemulsions in gel form. On incorporation of indomethacin only four formulae remain stable, clear formulae. They were used for further studies. Their order of drug release rate was first order. The four formulae were stable when stored at room temperature, or under stress. Shelf life of them would be minimum of 492 days and maximum of 712 days.

Indomethacin significantly inhibits edema, induced in rat paw by different percentage. Effect of the prepared microemulsions were between the effect of commercial injection form, highest effect, and commercial topical form, lowest effect.

Conclusions

The microemulsion formulae prepared with paraffin oil, brij97, sorbitol or glycerol and water showed acceptable physical properties, drug release, stability and Pharmacodynamic effect.