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A meta-analysis of the eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease

by Mohammed A. Amin 1,*
1
Faculty of Pharmacy, Beni-Suef University
*
Author to whom correspondence should be addressed.
IJCMR  2023, 1; 1(1), 1; https://doi.org/10.61466/ijcmr1010001
Received: 29 June 2023 / Accepted: 1 August 2023 / Published Online: 2 August 2023

Abstract

Background

We conducted a meta-analysis to assess the eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease.

There are now a variety of viewpoints on eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease, and there are not many thorough assessments that are pertinent.

Methods

A systematic literature search up to July 2022 was performed and 2378 related studies were evaluated. The chosen studies comprised 1800 children without obvious gastrointestinal disease participated in the selected studies' baseline trials; 607 of them were colonic eosinophilia, while 1193 were normal. Odds ratio (OR), and mean difference (MD) with 95% confidence intervals (CIs) were calculated to assess the eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease by the dichotomous, and contentious methods with a random or fixed effect model.

Results

The colonic eosinophilia resulted in significantly higher cell counts in the duodenum and terminal ileum (MD, 9.66; 95% CI, 6.50-12.81, p<0.001) compared to the normal for children without obvious gastrointestinal disease.

However, no significant difference was found between colonic eosinophilia and normal for children without obvious gastrointestinal disease in cell counts in the large intestine and the rectum (MD, 13.25; 95% CI, 0.17-26.33, p=0.05).

Conclusions

The colonic eosinophilia resulted-in-significantly-higher-cell-counts-in-the-duodenum-and-terminal-ileum,-however,-no-significant-difference-was-found-in-cell-counts-in-the-large-intestine-and-the rectum compared to the normal for children without obvious gastrointestinal disease. The small sample size of 8 studies out of 15 and the small number of studies in certain comparisons calls for care when analyzing the results.


Copyright: © 2023 by A. Amin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
A. Amin, M. A meta-analysis of the eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease. International Journal of Clinical Medical Research, 2023, 1, 1. https://doi.org/10.61466/ijcmr1010001
AMA Style
A. Amin M. A meta-analysis of the eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease. International Journal of Clinical Medical Research; 2023, 1(1):1. https://doi.org/10.61466/ijcmr1010001
Chicago/Turabian Style
A. Amin, Mohammed 2023. "A meta-analysis of the eosinophil counts in the small intestine and colon of children without obvious gastrointestinal disease" International Journal of Clinical Medical Research 1, no.1:1. https://doi.org/10.61466/ijcmr1010001

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