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Open Access Journal Article

The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension in different degrees

by Mykhailo Lutai 1 ,  Ilona Golikova 1,*  and  Nataliia Chubko 1
1
State institution"National Scientific Center "The M.D. Strazhesko institute of cardiology, clinical and regenerative medicine of the National academy of medical sciences of Ukraine”
*
Author to whom correspondence should be addressed.
IJCMR  2025 3(1):48; https://doi.org/10.61466/ijcmr3010003
Received: 19 December 2024 / Accepted: 9 January 2025 / Published Online: 10 January 2025
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Abstract

The use of beta-blockers (bisoprolol) and ACE inhibitors (perindopril) is pathogenetically and clinically justified in patients with stable coronary artery disease (CAD) and concomitant arterial hypertension (AH) . The study showed that prescribing a fixed combination of previously used drugs (perindopril, bisoprolol) for 4 weeks in patients with clinical symptoms or documented CAD can effectively reduce heart rate (HR) and blood pressure (BP) (heart rate levels ≤ 70 bpm were reached in 84.9%, blood pressure ≤ 140/90 mm Hg - 86.9% of patients), reduces the number of angina attacks from 4.4 to 2.6 per week and the need for nitroglycerin - from 4.8 to 2.7 tablets per week, and improve adherence to therapy (66.5% of patients). 

Keywords: fixed double combination therapy; bisoprolol; perindopril; stable coronary artery disease; arterial hypertension;
Copyright: © 2025 by Lutai, Golikova and Chubko. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Lutai, M.; Golikova, I.; Chubko, N. The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension in different degrees. International Journal of Clinical Medical Research, 2025, 3, 48. https://doi.org/10.61466/ijcmr3010003
AMA Style
Lutai M, Golikova I, Chubko N. The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension in different degrees. International Journal of Clinical Medical Research; 2025, 3(1):48. https://doi.org/10.61466/ijcmr3010003
Chicago/Turabian Style
Lutai, Mykhailo; Golikova, Ilona; Chubko, Nataliia 2025. "The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension in different degrees" International Journal of Clinical Medical Research 3, no.1:48. https://doi.org/10.61466/ijcmr3010003
APA style
Lutai, M., Golikova, I., & Chubko, N. (2025). The effectiveness of a fixed double combination (bisoprolol, perindopril) in patients with stable coronary artery disease and arterial hypertension in different degrees. International Journal of Clinical Medical Research, 3(1), 48. https://doi.org/10.61466/ijcmr3010003

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References

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