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Open Access Journal Article

Local and Systemic side effects of COVID-19 Vaccines

by Ahmed D. Alatawi 1 ,  Marwa O. Elgendy 2,3,* ,  Ahmed M. Sayed 4 ,  Shafiq Naguib Shafiq 5 ,  Ali H. El-Bahrawy 6 ,  Tauqeer Hussain Mallhi 1 ,  Yusra Habib Khan 1 ,  Abdulaziz Ibrahim Alzarea 1 ,  Nasser Hadal Alotaibi 1  and  Abdullah Salah Alanazi 1
1
Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia
2
Department of Clinical Pharmacy, Beni-Suef University Hospitals, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
3
Department of Clinical Pharmacy, Faculty of Pharmacy, Nahda University, Egypt
4
Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni-Suef 62513, Egypt
5
Internal Medicine Department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62521, Egypt
6
Department of Clinical Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt
*
Author to whom correspondence should be addressed.
IJCMR  2023, 17; 2(1), 17; https://doi.org/10.61466/ijcmr2010002
Received: 8 November 2023 / Accepted: 13 December 2023 / Published Online: 14 December 2023
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Abstract

Background:

To increase the public's acceptance of the vaccine, knowledge of its side effects is crucial. Thus, the purpose of this study was to identify side effects in the Saudi population following vaccinations with Pfizer BioNTech and AstraZeneca.

Method:

In Saudi Arabia, an online survey was conducted between March and October of 2021. Participants from Saudi Arabia who received two doses of the Pfizer BioNTech or AstraZeneca vaccine took part. The survey identified side effects following vaccinations.

Results:

AstraZeneca and Pfizer BioNTech administered vaccines to 174 and 224 of the 398 subjects, respectively. Fatigue (83.9%), local pain (78.2%), bone or joint pain (74.1%), fever (67.8%), vomiting or loss of appetite (24.1%), swelling (24.1%), and redness (21.8%) were the most commonly reported side effects for participants who took AstraZeneca. 

For the participants who received Pfizer BioNTech, the most common adverse effects that were reported were fatigue (43.8%), bone or joint pain (38.4%), swelling (28.6%), fever (22.8%), redness (15.1%), and nausea or vomiting (11.2%). Local pain accounted for 90.6% of the adverse effects that participants reported.

Conclusions:

After receiving the COVID-19 vaccine, the majority of participants reported experiencing at least one side effect. Whereas the AstraZeneca vaccination was linked to a higher prevalence of systemic side effects, the Pfizer BioNTech vaccination was linked to a higher prevalence of local adverse effects. Most adverse events following vaccination are not fatal. After receiving an AstraZeneca or Pfizer BioNTech vaccination, side effects were more common in women and younger age groups. Vaccinations against coronavirus have a good safety record.

Keywords: Pfizer BioNTech; AstraZeneca; COVID-19 vaccine; vaccine side effects;
Copyright: © 2023 by Alatawi, Elgendy, Sayed, Shafiq, El-Bahrawy, Mallhi, Khan, Alzarea, Alotaibi and Alanazi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Alatawi, A. D.; Elgendy, M. O.; Sayed, A. M.; Shafiq, S. N.; El-Bahrawy, A. H.; Mallhi, T. H.; Khan, Y. H.; Alzarea, A. I.; Alotaibi, N. H.; Alanazi, A. S. Local and Systemic side effects of COVID-19 Vaccines. International Journal of Clinical Medical Research, 2024, 2, 17. https://doi.org/10.61466/ijcmr2010002
AMA Style
Alatawi A D, Elgendy M O, Sayed A M, Shafiq S N, El-Bahrawy A H, Mallhi T H, Khan Y H, Alzarea A I, Alotaibi N H, Alanazi A S. Local and Systemic side effects of COVID-19 Vaccines. International Journal of Clinical Medical Research; 2024, 2(1):17. https://doi.org/10.61466/ijcmr2010002
Chicago/Turabian Style
Alatawi, Ahmed D.; Elgendy, Marwa O.; Sayed, Ahmed M.; Shafiq, Shafiq N.; El-Bahrawy, Ali H.; Mallhi, Tauqeer H.; Khan, Yusra H.; Alzarea, Abdulaziz I.; Alotaibi, Nasser H.; Alanazi, Abdullah S. 2024. "Local and Systemic side effects of COVID-19 Vaccines" International Journal of Clinical Medical Research 2, no.1:17. https://doi.org/10.61466/ijcmr2010002

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