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Open Access Journal Article

Effect of Budesonide and Systemic Corticosteroids on Hospital Admissions and Length of Stay: A Meta-analysis

by Ahmed S. Shafiey 1,*  and  Hend Ahmed 1
1
Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt
*
Author to whom correspondence should be addressed.
IJCMR  2025 3(2):52; https://doi.org/10.61466/ijcmr3020002
Received: 1 January 2025 / Accepted: 19 February 2025 / Published Online: 19 February 2025
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Abstract

Background

Asthma is a common chronic illness in children, contributing significantly to healthcare costs and morbidity. Despite the use of systemic corticosteroids (SC) as the standard treatment for acute asthma, their delayed onset and incomplete efficacy in reducing hospitalization have led to interest in inhaled corticosteroids (ICS) as adjunctive therapy.

Methods

This meta-analysis aimed to evaluate the efficacy of combining budesonide (an ICS) with SC in children with acute asthma. A systematic search of databases identified 10 studies involving 1,588 children, of whom 794 received budesonide in addition to SC, while the remaining 794 received SC alone.

Results

The addition of budesonide was associated with a non-significant reduction in hospital admission rates (OR 0.48, 95% CI 0.25–0.91, p=0.02) and length of stay. Studies with higher doses of budesonide (≥2mg) showed a greater but still non-significant improvement in asthma severity scores.

Conclusions

While combining ICS and SC resulted in a potential cost-effective benefit, further trials with higher doses of budesonide are needed. Major limitations include the absence of studies involving MDI-based ICS delivery, limited data on lung function, and the lack of recent trials after 2020.

Keywords: ;
Copyright: © 2025 by Shafiey and Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ACS Style
Shafiey, A. S.; Ahmed, H. Effect of Budesonide and Systemic Corticosteroids on Hospital Admissions and Length of Stay: A Meta-analysis. International Journal of Clinical Medical Research, 2025, 3, 52. doi:10.61466/ijcmr3020002
AMA Style
Shafiey A S, Ahmed H. Effect of Budesonide and Systemic Corticosteroids on Hospital Admissions and Length of Stay: A Meta-analysis. International Journal of Clinical Medical Research; 2025, 3(2):52. doi:10.61466/ijcmr3020002
Chicago/Turabian Style
Shafiey, Ahmed S.; Ahmed, Hend 2025. "Effect of Budesonide and Systemic Corticosteroids on Hospital Admissions and Length of Stay: A Meta-analysis" International Journal of Clinical Medical Research 3, no.2:52. doi:10.61466/ijcmr3020002

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