Login / Register Submit Your Article
cover
Article Menu
Journal Browser
Vol. 2 (2024)
Vol. 1 (2023)
Indexing and Partners

Google scholar

Crossref

Open Access Journal Article

A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies

by Yaieo Koang 1,*
1
Department of Stomatology, Xinxeiang Central Hospital, The Fourth Clinical College of Xinxeiang Medical University, Henan, 453000, China
*
Author to whom correspondence should be addressed.
IJCMR  2024 2(4):32; https://doi.org/10.61466/ijcmr2040002
Received: 21 May 2024 / Accepted: 22 July 2024 / Published Online: 10 July 2024
View Full-Text
Download PDF

Abstract

Background:

A meta-analysis research was implemented to appraise gingival wound healing management by photobiomodulation as adjunctive management to periodontal treatments.

Inclusive literature research till April 2023 was done and 908 interconnected researches were revised. Methods

The 9 picked researches, enclosed 517 periodontal disease persons were in the utilized researchers' starting point, 258 of them were utilizing photobiomodulation, and 259 were control. Odds ratio (OR) and 95% confidence intervals (CIs) were utilized to appraise the consequence of photobiomodulation in treating gingival wound healing by the dichotomous, and contentious approach and a fixed or random model.

Results:

Photobiomodulation had a significantly higher Landry wound healing index (MD, 0.87; 95% CI, 0.40-1.34, p<0.001), and complete wound epithelialization (OR, 6.47; 95% CI, 2.05-20.44, p=0.001) compared to the control of gingival wound healing in periodontal disease persons. However, photobiomodulation and control had no significant difference in the remaining wound area (MD, -10.03; 95% CI, -22.83-2.77, p=0.12) of gingival wound healing in periodontal disease persons.

Conclusions:

Photobiomodulation had a significantly higher Landry wound healing index, and complete wound epithelialization, however, no significant difference was found in the remaining wound area compared to control of gingival wound healing in periodontal disease persons. However, caution needs to be taken when interacting with its values since there was a low sample size of most of the chosen research found for the comparisons in the meta-analysis and a low number of chosen investigations for some of the comparisons.

Keywords: complete wound epithelialization; photobiomodulation; periodontal disease; remaining wound area of the wound; Landry wound healing index;
Copyright: © 2024 by Koang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (Creative Commons Attribution 4.0 International License). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

Share and Cite

ACS Style
Koang, Y. A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies. International Journal of Clinical Medical Research, 2024, 2, 32. https://doi.org/10.61466/ijcmr2040002
AMA Style
Koang Y. A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies. International Journal of Clinical Medical Research; 2024, 2(4):32. https://doi.org/10.61466/ijcmr2040002
Chicago/Turabian Style
Koang, Yaieo 2024. "A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies" International Journal of Clinical Medical Research 2, no.4:32. https://doi.org/10.61466/ijcmr2040002
APA style
Koang, Y. (2024). A meta-analysis on the use of photobiomodulation to regulate gingival wound healing in addition to periodontal therapies. International Journal of Clinical Medical Research, 2(4), 32. https://doi.org/10.61466/ijcmr2040002

Article Metrics

Article Access Statistics

References

  1. Rojas, M., L. Marini, A. Pilloni, and P. Sahrmann, Early wound healing outcomes after regenerative periodontal surgery with enamel matrix derivatives or guided tissue regeneration: a systematic review. BMC Oral Health, 2019. 19: p. 1-16.
  2. Eli, I., D. Schwartz‐Arad, R. Baht, and H. Ben‐Tuvim, Effect of anxiety on the experience of pain in implant insertion. Clinical oral implants research, 2003. 14(1): p. 115-118.
  3. Kim, S., Y.-J. Lee, S. Lee, H.-S. Moon, and M.-K. Chung, Assessment of pain and anxiety following surgical placement of dental implants. International journal of oral & maxillofacial implants, 2013. 28(2).
  4. Mei, C.C., F.Y. Lee, and H.C. Yeh, Assessment of pain perception following periodontal and implant surgeries. Journal of Clinical Periodontology, 2016. 43(12): p. 1151-1159.
  5. Gkatzonis, A.M., S.I. Vassilopoulos, I.K. Karoussis, A. Kaminari, P.N. Madianos, and I.A. Vrotsos, A randomized controlled clinical trial on the effectiveness of three different mouthrinses (chlorhexidine with or without alcohol and C31G), adjunct to periodontal surgery, in early wound healing. Clinical Oral Investigations, 2018. 22: p. 2581-2591.
  6. Lee, J., J.-C. Park, U.-W. Jung, S.-H. Choi, K.-S. Cho, Y.-K. Park, and C.-S. Kim, Improvement in periodontal healing after periodontal surgery supported by nutritional supplement drinks. Journal of periodontal & implant science, 2014. 44(3): p. 109-117.
  7. Dastoor, S.F., S. Travan, R.F. Neiva, L.A. Rayburn, W.V. Giannobile, and H.L. Wang, Effect of adjunctive systemic azithromycin with periodontal surgery in the treatment of chronic periodontitis in smokers: a pilot investigation. Journal of Periodontology, 2007. 78(10): p. 1887-1896.
  8. Bashutski, J., R. Eber, J. Kinney, E. Benavides, S. Maitra, T. Braun, W. Giannobile, and L. McCauley, The impact of vitamin D status on periodontal surgery outcomes. Journal of dental research, 2011. 90(8): p. 1007-1012.
  9. Westeelt, E., S. Nyman, S. Socransky, and J. Lindhe, Significance of frequency of professional tooth cleaning for healing following periodontal surgery. Journal of clinical periodontology, 1983. 10(2): p. 148-156.
  10. Pulikkotil, S.J. and S. Nath, Fibrin sealant as an alternative for sutures in periodontal surgery. J Coll Physicians Surg Pak, 2013. 23(2): p. 164-5.
  11. Hupp, J.R., M.R. Tucker, and E. Ellis, Contemporary Oral and maxillofacial surgery-E-book. 2013: Elsevier health sciences.
  12. Yildiz, M.S. and S. Gunpinar, Free gingival graft adjunct with low-level laser therapy: a randomized placebo-controlled parallel group investigation. Clinical oral investigations, 2019. 23: p. 1845-1854.
  13. Hamblin, M.R., Mechanisms and applications of the anti-inflammatory effects of photobiomodulation. AIMS biophysics, 2017. 4(3): p. 337.
  14. Dompe, C., L. Moncrieff, J. Matys, K. Grzech-Leśniak, I. Kocherova, A. Bryja, M. Bruska, M. Dominiak, P. Mozdziak, and T.H.I. Skiba, photobiomodulation—underlying mechanism and clinical applications. Journal of clinical medicine, 2020. 9(6): p. 1724.
  15. Heidari, M., R. Fekrazad, F. Sobouti, M. Moharrami, S. Azizi, H. Nokhbatolfoghahaei, and M. Khatami, Evaluating the effect of photobiomodulation with a 940-nm diode laser on postoperative pain in periodontal flap surgery. Lasers in Medical Science, 2018. 33: p. 1639-1645.
  16. Bereșescu, G., M. Monea, B. Porca, A. Cocan, and A.M. Monea. Effects of low level laser therapy on bone regeneration of intrabony defects. in Key Engineering Materials. 2015. Trans Tech Publ.
  17. Neda, M., H. Mohadeseh, F. Reza, N. Hanieh, Y. Siamak, S. Ahmadreza, and P. Mozhgan, Effect of 660nm low power laser on pain and healing in palatal donor sites; a randomized controlled clinical trial. 2014.
  18. Stroup, D.F., J.A. Berlin, S.C. Morton, I. Olkin, G.D. Williamson, D. Rennie, D. Moher, B.J. Becker, T.A. Sipe, and S.B. Thacker, Meta-analysis of observational investigations in epidemiology: a proposal for reporting. Jama, 2000. 283(15): p. 2008-2012.
  19. Liberati, A., D.G. Altman, J. Tetzlaff, C. Mulrow, P.C. Gøtzsche, J.P. Ioannidis, M. Clarke, P.J. Devereaux, J. Kleijnen, and D. Moher, The PRISMA statement for reporting systematic reviews and meta-analyses of investigations that evaluate health care interventions: explanation and elaboration. Journal of clinical epidemiology, 2009. 62(10): p. e1-e34.
  20. Gupta, S., G. Rout, A.H. Patel, M. Mahanta, N. Kalra, P. Sahu, R. Sethia, A. Agarwal, G. Ranjan, and S. Kedia, Efficacy of generic oral directly acting agents in patients with hepatitis C virus infection. Journal of viral hepatitis, 2018. 25(7): p. 771-778.
  21. Sheikhbahaei, S., T.J. Trahan, J. Xiao, M. Taghipour, E. Mena, R.M. Connolly, and R.M. Subramaniam, FDG-PET/CT and MRI for evaluation of pathologic response to neoadjuvant chemotherapy in patients with breast cancer: a meta-analysis of diagnostic accuracy investigations. The oncologist, 2016. 21(8): p. 931-939.
  22. Higgins, J.P., S.G. Thompson, J.J. Deeks, and D.G. Altman, Measuring inconsistency in meta-analyses. Bmj, 2003. 327(7414): p. 557-560.
  23. Ozcelik, O., M. Cenk Haytac, A. Kunin, and G. Seydaoglu, Improved wound healing by low‐level laser irradiation after gingivectomy operations: a controlled clinical pilot investigation. Journal of clinical periodontology, 2008. 35(3): p. 250-254.
  24. Ustaoglu, G., E. Ercan, and M. Tunali, Low-level laser therapy in enhancing wound healing and preserving tissue thickness at free gingival graft donor sites: a randomized, controlled clinical investigation. Photomedicine and laser surgery, 2017. 35(4): p. 223-230.
  25. Heidari, M., M. Paknejad, R. Jamali, H. Nokhbatolfoghahaei, R. Fekrazad, and N. Moslemi, Effect of laser photobiomodulation on wound healing and postoperative pain following free gingival graft: A split-mouth triple-blind randomized controlled clinical trial. Journal of Photochemistry and Photobiology B: Biology, 2017. 172: p. 109-114.
  26. Kohale, B.R., A.A. Agrawal, and C.P. Raut, Effect of low-level laser therapy on wound healing and patients' response after scalpel gingivectomy: A randomized clinical split-mouth investigation. Journal of Indian Society of Periodontology, 2018. 22(5): p. 419.
  27. Isler, S.C., A. Uraz, B. Guler, Y. Ozdemir, S. Cula, and D. Cetiner, Effects of laser photobiomodulation and ozone therapy on palatal epithelial wound healing and patient morbidity. Photomedicine and laser surgery, 2018. 36(11): p. 571-580.
  28. Lingamaneni, S., L.R. Mandadi, and K.R. Pathakota, Assessment of healing following low-level laser irradiation after gingivectomy operations using a novel soft tissue healing index: A randomized, double-blind, split-mouth clinical pilot investigation. Journal of Indian Society of Periodontology, 2019. 23(1): p. 53.
  29. Morshedzadeh, G., H. Aslroosta, and M. Vafaei, Effect of GaAlAs 940 nm photobiomodulation on palatal wound healing after free gingival graft surgery: a split mouth randomized controlled clinical trial. BMC Oral Health, 2022. 22(1): p. 202.
  30. Bozkurt, E. and M.Ö. Uslu, Evaluation of the effects of platelet-rich fibrin, concentrated growth factors, and autologous fibrin glue application on wound healing following gingivectomy and gingivoplasty operations: a randomized controlled clinical trial. Quintessence International, 2022. 53(4): p. 328-341.
  31. Misra, P., R. Kalsi, S.A. Arora, K.S. Singh, S. Athar, A. Saini, and A. Saini Sr, Effect of Low-Level Laser Therapy on Early Wound Healing and Levels of Inflammatory Mediators in Gingival Crevicular Fluid Following Open Flap Debridement. Cureus, 2023. 15(2).
  32. Sommer, A.P., P. Schemmer, A.E. Pavláth, H.-D. Försterling, Á.R. Mester, and M.A. Trelles, Quantum biology in low level light therapy: death of a dogma. Annals of Translational Medicine, 2020. 8(7).
  33. Keskiner, I., M. Lutfioğlu, A. Aydogdu, N.I. Saygun, and M.A. Serdar, Effect of photobiomodulation on transforming growth factor-β1, platelet-derived growth factor-BB, and interleukin-8 release in palatal wounds after free gingival graft harvesting: a randomized clinical investigation. Photomedicine and laser surgery, 2016. 34(6): p. 263-271.
  34. Zhao, H., J. Hu, and L. Zhao, The effect of low-level laser therapy as an adjunct to periodontal surgery in the management of postoperative pain and wound healing: a systematic review and meta-analysis. Lasers in Medical Science, 2021. 36(1): p. 175-187.
  35. Talluri, S., M. Altuhafy, and J. Khan, The Efficacy of photobiomodulation in Wound healing following Gingivectomy: A systematic Review of clinical Investigations. International Journal of Experimental Dental Science, 2023. 10(2): p. 63-70.
  36. Malekzadeh, M., D. Maleki, and M. Zohary, Effect of adjunctive low level laser therapy on gingival graft: A Review of the Literature. Journal of Dentomaxillofacial Radiology, Pathology and Surgery, 2022. 11(1): p. 7-13.